2009年3月10日星期二

my CV

Chun-Hong Chen

WORK ADDRESS: HOME ADDRESS:

Division of Molecular and Genomic Medicine

National Heath Research Institutes

35 Kayen Road Zhunan Mioali

Tel.: 037-246-166 #35347, Fax. : 037-586459

E-mail: chunhong@nhri.org.tw


EDUCATION

B.S., National Taiwan University, Dep. of Plant Pathology and Entomology, 1991

M.S., National Taiwan University, Institute of Plant Pathology, Virology laboratory, 1995

Ph.D., National Yang-Ming University, Institute of Microbiology and Immunology, 2001

EXPERIENCE

2009 Assistant Research Fellow

Division of Molecular and Genomic Medicine

National Heath Research Institutes

2008-2009

Senior Research Fellow Department of Biology, Caltech

2003-2008

Postdoctoral fellow, Department of Biology, Caltech

With Dr. Bruce Hay

Research Topic:

MicroRNAs, a new family of cell death regulator

A maternal effect selfish genetic element for insect control

MicroRNAs-based RNAi system

Study Caspase function in cell death and non-cell death pathway.

2001-2003

Postdoctoral fellow, Academia Sinica, Taipei, Taiwan

With Dr. Soo-Chen Cheng

Research Topic:

Functional links between the Prp19-associated complex, U4/U6 biogenesis, and spliceosome recycling

1995-2001

Graduate Research Ph.D. program

Institute of Molecular Biology, Academia Sinica.

National Yang-Ming University, Institute of Microbiology and Immunology

With Dr. Soo-Chen Cheng

Research Topic: mRNA splicing in yeast

Characterization of the protein factors in the Prp19-associated complex

1993-1995

Master Graduate Student,

Laboratory of Plant Virology, Institute of Plant Pathology, National Taiwan University

Institute of Molecular Biology, Academia Sinica

with Dr. Yu-Chan Chao and Dr. Hong-Ji Su

Research Topic: Genome structure of Banana Bunchy Top Virus

1991-1993

2nd Lieutenant, Military Service in the Army.

1987-1991

Undergraduate Student, with Dr. Dr. Hong-Ji Su

Laboratory of Plant Virology, Institute of Plant Pathology, National Taiwan University

Research Topic: Sugarcane Mosaic Virus

FELLOSHIPS AND AWARDS:

1994

Award of Plant Pathology NTU sponsored by Dr. Motumato

1996-1997

Award of Excellent Student Fellowship by International Rotary Club

1999

Travel fellowship by Foundation for Advancement of Outstanding Scholars (RNA meeting, Edinburgh U.K.)

2001

Award of Dr. Chien-Tien Hsu Prize First place

The Dr. Chien-Tien Hsu Prize is awarded every year for the best Ph.D. thesis by the Society of Cellular and Molecular Biology in Taiwan

2001

Travel fellowship by Foundation for Advancement of Outstanding Scholars (RNA meeting, Banff Canada)

2002

Travel fellowship by Foundation for Advancement of Outstanding Scholars (RNA meeting, Madison WI U.S.A.)

2003-2005

Gosney Foundation Postdoctoral Fellowship, Caltech Biology

2005-2006

Fellowship Moore Foundation Center for Biological Circuit Design


LIST OF PUBLICATIONS

1. Chen, H.-R., Tsao, T.-Y., Chen, C.-H., Tsai, W.-Y., Her, L.-S., Hsu, M.-T. and Cheng, S.-C. (1999) Snt309p modulates interactions of Prp19p with its associated components to stabilize a protein complex essential for pre-mRNA splicing. Proc. Natl. Acad. Sci. USA 96, 5406-5411.

2. Tsai, W.-Y., Chow, I.-T., Chen, H.-R., Huang, K.-T., Hong, R.-I., Jan, S.-P., Kuo, N.-Y., Tsao, T.-Y., Chen, C.-H., and Cheng, S.-C. (1999) Cef1p is a component of the Prp19p-associated complex and essential for pre-mRNA splicing. J. Biol. Chem. 274, 9455-9462.

3. Chen, C.-H., Tsai, W.-Y., Chen, H.-R., Wang, C.-H., and Cheng, S,-C. (2001) Identification and characterization of two novel components of the Prp19p-associated complex, Ntc30p and Ntc20p J. Biol. Chem. 276: 488-494.

4 Chen, C.-H., Yu, W.-C., Taso, T.-Y., Wang, L.-Y., Chen, H.-R., Lin, J.-Y., Tsai, W.-Y., and Cheng, S,-C. (2002) Functional and physical interactions between components of the Prp19p-associated complex Nuclear Acid Research 30:1029-1037

5 Chen C.-H., Kao D.-I., Chan S.-P., Kao T.-C., Lin J.-Y., Cheng S.-C.

Functional links between the Prp19-associated complex, U4/U6 biogenesis, and spliceosome recycling. (2006)
RNA. (5):765-74

6 Muro I, Berry D.L, Huh J.R, Chen C.-H., Huang H, Yoo S.J, Guo M, Baehrecke EH, Hay BA.

The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process. (2006)
Development.;133(17):3305-15.

7 Chen C.-H., Guo M, Hay BA.

Identifying microRNA regulators of cell death in Drosophila. (2006)
Methods Mol Biol. 342:229-40. Review.

8 Huh JR, Foe I, Muro I, Chen C.-H, Seol JH, Yoo SJ, Guo M, Park JM, Hay BA.

The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis inducers. (2007) J Biol Chem. 282(3):2056-68.

9 Chen C.-H., Huang H., Ward CM., Su JT., Schaeffer LV., Guo M., Hay BA .(2007)

A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila. Science 316(5824):597-600.

This paper is featured by

Science (2007) 315(5820):1777-1778

Nature review of Genetic (2007) 8 (5) 324

Bioscience (2007) 57(10) 816-821

The Scientist News March-29 2007

Scientific American Top 50 of 2007

Top-10 papers by Faculty 1000 Medicine, May 2007

10 Shcherbata H.R., Ward E.J., Fischer K.A., Yu J-Y., Reynolds S., Chen C.-H., Xu P., Hay B.A., Ruohola-Baker H. (2007) Stem cell robustness through a compensatory maintained pathway in the Drosophila germ line. (2007) Cell stem cell 6 (1) 698-709

11 Yao J.-G., Weasner B.M., Wang L.-H., Jang C.-C., Tang C.-Y., Salzer C.L., Chen C.-H., Hay B.A., Sun Y.H., Justin P.(2008) Differential requirement of the Pax(5a) genes eyegone and twin of eyegone during eye development in Drosophila. Developmental Biology 315(2):535-51.

12 Sriram Sathyanarayanan1, Xiangzhong Zheng, Shailesh Kumar, Chun-Hong Chen, Dechun Chen, Bruce Hay and Amita Sehgal(2008)

Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen. Genes and Development 22(11):1522-33

13 Yu, H-H. Chen, C-H., Huang, Y., Lin, S., and Lee, T

Neuronal lineage and birth order analysis with twin-spot MARCM

Nature Neuroscience ( 2009 )12(7):947-53.


2009年3月4日星期三

publications

Yu, H-H. Chen, C-H., Huang, Y., Lin, S., and Lee, T ( 200

Neuronal lineage and birth order analysis with twin-spot MARCM Nature Neuroscience ( 2009 )12(7):947-53.

Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen.

Sathyanarayanan S, Zheng X, Kumar S, Chen CH, Chen D, Hay B, Sehgal A.

Genes Dev. 2008 Jun 1;22(11):1522-33.

PMID: 18519643 [PubMed - indexed for MEDLINE]

2:

Differential requirements for the Pax6(5a) genes eyegone and twin of eyegone during eye development in Drosophila.

Yao JG, Weasner BM, Wang LH, Jang CC, Weasner B, Tang CY, Salzer CL, Chen CH, Hay B, Sun YH, Kumar JP.

Dev Biol. 2008 Mar 15;315(2):535-51. Epub 2008 Jan 4.

PMID: 18275947 [PubMed - indexed for MEDLINE]

3:

Stage-specific differences in the requirements for germline stem cell maintenance in the Drosophila ovary.

Shcherbata HR, Ward EJ, Fischer KA, Yu JY, Reynolds SH, Chen CH, Xu P, Hay BA, Ruohola-Baker H.

Cell Stem Cell. 2007 Dec 13;1(6):698-709.

PMID: 18213359 [PubMed - indexed for MEDLINE]

4:

A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila.

Chen CH, Huang H, Ward CM, Su JT, Schaeffer LV, Guo M, Hay BA.

Science. 2007 Apr 27;316(5824):597-600. Epub 2007 Mar 29.

PMID: 17395794 [PubMed - indexed for MEDLINE]

6:

Identifying microRNA regulators of cell death in Drosophila.

Chen CH, Guo M, Hay BA.

Methods Mol Biol. 2006;342:229-40. Review.

PMID: 16957378 [PubMed - indexed for MEDLINE]

7:

The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process.

Muro I, Berry DL, Huh JR, Chen CH, Huang H, Yoo SJ, Guo M, Baehrecke EH, Hay BA.

Development. 2006 Sep;133(17):3305-15. Epub 2006 Aug 3.

PMID: 16887831 [PubMed - indexed for MEDLINE]

8:

Functional links between the Prp19-associated complex, U4/U6 biogenesis, and spliceosome recycling.

Chen CH, Kao DI, Chan SP, Kao TC, Lin JY, Cheng SC.

RNA. 2006 May;12(5):765-74. Epub 2006 Mar 15.

PMID: 16540691 [PubMed - indexed for MEDLINE]

9:

Functional and physical interactions between components of the Prp19p-associated complex.

Chen CH, Yu WC, Tsao TY, Wang LY, Chen HR, Lin JY, Tsai WY, Cheng SC.

Nucleic Acids Res. 2002 Feb 15;30(4):1029-37.

PMID: 11842115 [PubMed - indexed for MEDLINE]

10:

Identification and characterization of two novel components of the Prp19p-associated complex, Ntc30p and Ntc20p.

Chen CH, Tsai WY, Chen HR, Wang CH, Cheng SC.

J Biol Chem. 2001 Jan 5;276(1):488-94.

PMID: 11018040 [PubMed - indexed for MEDLINE]

11:

Snt309p modulates interactions of Prp19p with its associated components to stabilize the Prp19p-associated complex essential for pre-mRNA splicing.

Chen HR, Tsao TY, Chen CH, Tsai WY, Her LS, Hsu MM, Cheng SC.

Proc Natl Acad Sci U S A. 1999 May 11;96(10):5406-11.

PMID: 10318896 [PubMed - indexed for MEDLINE]

12:

Cef1p is a component of the Prp19p-associated complex and essential for pre-mRNA splicing.

Tsai WY, Chow YT, Chen HR, Huang KT, Hong RI, Jan SP, Kuo NY, Tsao TY, Chen CH, Cheng SC.

J Biol Chem. 1999 Apr 2;274(14):9455-62.

PMID: 10092627 [PubMed - indexed for MEDLINE]

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