Chun-Hong Chen
WORK ADDRESS: HOME ADDRESS:
Division of Molecular and Genomic Medicine
National Heath Research Institutes
35 Kayen Road Zhunan Mioali
Tel.: 037-246-166 #35347, Fax. : 037-586459
E-mail: chunhong@nhri.org.tw
EDUCATION
B.S., National Taiwan University, Dep. of Plant Pathology and Entomology, 1991
M.S., National Taiwan University, Institute of Plant Pathology, Virology laboratory, 1995
Ph.D., National Yang-Ming University, Institute of Microbiology and Immunology, 2001
EXPERIENCE
2009 Assistant Research Fellow
Division of Molecular and Genomic Medicine
National Heath Research Institutes
2008-2009
Senior Research Fellow Department of Biology, Caltech
2003-2008
Postdoctoral fellow, Department of Biology, Caltech
With Dr. Bruce Hay
Research Topic:
MicroRNAs, a new family of cell death regulator
A maternal effect selfish genetic element for insect control
MicroRNAs-based RNAi system
Study Caspase function in cell death and non-cell death pathway.
2001-2003
Postdoctoral fellow, Academia Sinica, Taipei, Taiwan
With Dr. Soo-Chen Cheng
Research Topic:
Functional links between the Prp19-associated complex, U4/U6 biogenesis, and spliceosome recycling
1995-2001
Graduate Research Ph.D. program
Institute of Molecular Biology, Academia Sinica.
National Yang-Ming University, Institute of Microbiology and Immunology
With Dr. Soo-Chen Cheng
Research Topic: mRNA splicing in yeast
Characterization of the protein factors in the Prp19-associated complex
1993-1995
Master Graduate Student,
Laboratory of Plant Virology, Institute of Plant Pathology, National Taiwan University
Institute of Molecular Biology, Academia Sinica
with Dr. Yu-Chan Chao and Dr. Hong-Ji Su
Research Topic: Genome structure of Banana Bunchy Top Virus
1991-1993
2nd Lieutenant, Military Service in the Army.
1987-1991
Undergraduate Student, with Dr. Dr. Hong-Ji Su
Laboratory of Plant Virology, Institute of Plant Pathology, National Taiwan University
Research Topic: Sugarcane Mosaic Virus
FELLOSHIPS AND AWARDS:
1994
Award of Plant Pathology NTU sponsored by Dr. Motumato
1996-1997
Award of Excellent Student Fellowship by International Rotary Club
1999
Travel fellowship by Foundation for Advancement of Outstanding Scholars (RNA meeting, Edinburgh U.K.)
2001
Award of Dr. Chien-Tien Hsu Prize First place
The Dr. Chien-Tien Hsu Prize is awarded every year for the best Ph.D. thesis by the Society of Cellular and Molecular Biology in Taiwan
2001
Travel fellowship by Foundation for Advancement of Outstanding Scholars (RNA meeting, Banff Canada)
2002
Travel fellowship by Foundation for Advancement of Outstanding Scholars (RNA meeting, Madison WI U.S.A.)
2003-2005
Gosney Foundation Postdoctoral Fellowship, Caltech Biology
2005-2006
Fellowship Moore Foundation Center for Biological Circuit Design
LIST OF PUBLICATIONS
1. Chen, H.-R., Tsao, T.-Y., Chen, C.-H., Tsai, W.-Y., Her, L.-S., Hsu, M.-T. and Cheng, S.-C. (1999) Snt309p modulates interactions of Prp19p with its associated components to stabilize a protein complex essential for pre-mRNA splicing. Proc. Natl. Acad. Sci. USA 96, 5406-5411.
2. Tsai, W.-Y., Chow, I.-T., Chen, H.-R., Huang, K.-T., Hong, R.-I., Jan, S.-P., Kuo, N.-Y., Tsao, T.-Y., Chen, C.-H., and Cheng, S.-C. (1999) Cef1p is a component of the Prp19p-associated complex and essential for pre-mRNA splicing. J. Biol. Chem. 274, 9455-9462.
3. Chen, C.-H., Tsai, W.-Y., Chen, H.-R., Wang, C.-H., and Cheng, S,-C. (2001) Identification and characterization of two novel components of the Prp19p-associated complex, Ntc30p and Ntc20p J. Biol. Chem. 276: 488-494.
4 Chen, C.-H., Yu, W.-C., Taso, T.-Y., Wang, L.-Y., Chen, H.-R., Lin, J.-Y., Tsai, W.-Y., and Cheng, S,-C. (2002) Functional and physical interactions between components of the Prp19p-associated complex Nuclear Acid Research 30:1029-1037
5 Chen C.-H., Kao D.-I., Chan S.-P., Kao T.-C., Lin J.-Y., Cheng S.-C.
Functional links between the Prp19-associated complex, U4/U6 biogenesis, and spliceosome recycling. (2006)
RNA. (5):765-74
6 Muro I, Berry D.L, Huh J.R, Chen C.-H., Huang H, Yoo S.J, Guo M, Baehrecke EH, Hay BA.
The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process. (2006)
Development.;133(17):3305-15.
Identifying microRNA regulators of cell death in Drosophila. (2006)
Methods Mol Biol. 342:229-40. Review.
8 Huh JR, Foe I, Muro I, Chen C.-H, Seol JH, Yoo SJ, Guo M, Park JM, Hay BA.
The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis inducers. (2007) J Biol Chem. 282(3):2056-68.
9 Chen C.-H., Huang H., Ward CM., Su JT., Schaeffer LV., Guo M., Hay BA .(2007)
A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila. Science 316(5824):597-600.
This paper is featured by
Science (2007) 315(5820):1777-1778
Nature review of Genetic (2007) 8 (5) 324
Bioscience (2007) 57(10) 816-821
The Scientist News March-29 2007
Scientific American Top 50 of 2007
Top-10 papers by Faculty 1000 Medicine, May 2007
10 Shcherbata H.R., Ward E.J., Fischer K.A., Yu J-Y., Reynolds S., Chen C.-H., Xu P., Hay B.A., Ruohola-Baker H. (2007) Stem cell robustness through a compensatory maintained pathway in the Drosophila germ line. (2007) Cell stem cell 6 (1) 698-709
11 Yao J.-G., Weasner B.M., Wang L.-H., Jang C.-C., Tang C.-Y., Salzer C.L., Chen C.-H., Hay B.A., Sun Y.H., Justin P.(2008) Differential requirement of the Pax(5a) genes eyegone and twin of eyegone during eye development in Drosophila. Developmental Biology 315(2):535-51.
12 Sriram Sathyanarayanan1, Xiangzhong Zheng, Shailesh Kumar, Chun-Hong Chen, Dechun Chen, Bruce Hay and Amita Sehgal(2008)
Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen. Genes and Development 22(11):1522-33
13 Yu, H-H. Chen, C-H., Huang, Y., Lin, S., and Lee, T
Neuronal lineage and birth order analysis with twin-spot MARCM
Nature Neuroscience ( 2009 )12(7):947-53.
